Open AccessCondensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
Author(s) -
Wang JiDa,
Wang Li,
Yu Shuang,
Jin YuTong,
Wang YiYang,
Chai RunDong,
Zhao ZeYu,
Bian YuHong,
Zhao ShuWu
Publication year - 2022
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2982
Subject(s) - immunosuppression , immune system , spleen , levamisole , immunology , antibody , phagocytosis , cyclophosphamide , pharmacology , peripheral blood mononuclear cell , lymphocyte , biology , chemistry , medicine , in vitro , chemotherapy , biochemistry
Our general purpose was to examine the effect of condensed Fuzheng extract (CFE) on the alleviation of immunosuppression. A mouse model of immunosuppression was established by intraperitoneal injection of CTX. A healthy control group received no CTX and no CFE; different intragastric doses of CFE were administered to three groups of mice for 28 days (4500, 2250, or 1125 mg/kg/day); a negative control received CTX alone, and a positive control received CTX and levamisole hydrochloride. We evaluated the effects of CFE on the immune system organs, cells, and molecules by comparing the different groups. CFE significantly improved immune system organs (spleen and thymus indices and histology), stimulated immune cell activities (number of white blood cells and lymphocytes, phagocytosis of mononuclear phagocytes, proliferation of splenic lymphocytes, antibody formation, and NK cell activity), and increased the levels of immunoglobulins (IgA, IgG, and IgM) and cytokines (IL‐2 and IFN‐γ). Thus CFE effectively alleviated CTX‐mediated immunosuppression and oxidative stress and enhanced the immunological functions of mice.