Open AccessLactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
Author(s) -
Cao Kaihui,
Zhang Kaiping,
Ma Muran,
Ma Junjie,
Tian Jianjun,
Jin Ye
Publication year - 2021
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2600
Subject(s) - cholesterol 7 alpha hydroxylase , lactobacillus , biology , cholesterol , lipid metabolism , microbiology and biotechnology , bacteria , endocrinology , genetics
Abstract Hypercholesterolemia is the main cause of cardiovascular disease worldwide, and the regulation of cholesterol homeostasis is essential for human health. Lactobacillus is present in large quantities in the human intestine. As the normal flora in the gut, lactobacillus plays an important role in regulating metabolism in the human body. Lactobacillus can regulate the cholesterol content by regulating the expression of genes involved in cholesterol synthesis, metabolism, and absorption. This article reviews the biological effects and mechanisms of lactobacillus that mediate the expression of NPC1L1, CYP7A1, ABCG5, ABCG8, and other genes to inhibit cholesterol absorption, and discusses the mechanism of reducing cholesterol by lactobacillus in cells in vitro, to provide a theoretical basis for the development and utilization of lactobacillus resources.