Open AccessCalotropis procera (leaves) supplementation exerts curative effects on promoting functional recovery in a mouse model of peripheral nerve injury
Author(s) -
Zafar Shamaila,
Rasul Azhar,
Iqbal Javed,
Anwar Haseeb,
Imran Ali,
Jabeen Farhat,
Shabbir Asghar,
Akram Rabia,
Maqbool Javeria,
Sajid Faiqa,
Arshad Muhammad Umair,
Hussain Ghulam,
Islam Saiful
Publication year - 2021
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2455
Subject(s) - calotropis procera , procera , medicine , peripheral nerve injury , oxidative stress , sciatic nerve , peripheral , traditional medicine , pharmacology , anesthesia , biology , botany
Peripheral nerve injuries are among those complicated medical conditions, which are still waiting for their highly effective first‐line therapies. In this study, the role of Calotropis procera crude leaves was evaluated at different doses for their effectiveness in improving functional recovery following sciatic nerve injury‐induced in the mouse model. Thirty‐two healthy albino mice were divided into four groups as Normal chow group (control, n = 8) and C. procera chow groups (50 mg/kg ( n = 8), 100 mg/kg ( n = 8) and 200 mg/kg ( n = 8)). Behavioral analyses were performed to assess and compare improved functional recovery along with skeletal muscle mass measurement in all groups. Serum samples were analyzed for oxidative stress markers. Results showed that C. procera leaves at dose‐dependent manner showed statistically prominent ( p < .05) increase in sensorimotor functions reclamation as confirmed by behavioral analyses along with muscle mass restoration and prominent decline in TOS and momentous increase in TAC along with the augmented activity of antioxidative enzymes.