Open AccessAntidiabetic effects of the ethanolic extract of Allium saralicum R.M. Fritsch on streptozotocin‐induced diabetes in a mice model
Author(s) -
Fazelipour Simin,
Hadipour Jahromy Mahsa,
Tootian Zahra,
Goodarzi Nader
Publication year - 2021
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2405
Subject(s) - streptozotocin , diabetes mellitus , glibenclamide , oxidative stress , superoxide dismutase , creatinine , antioxidant , catalase , medicine , lipid profile , endocrinology , pharmacology , chemistry , biochemistry
Medicinal plants can protect different organs against diabetes‐induced oxidative stress due to their antioxidant compounds. The present study was designed to investigate the potential of Allium saralicum R.M. Fritsch (A. saralicum) ethanolic extract to alleviate the adverse effects of streptozotocin (STZ)‐induced diabetes in male BALB/c mice. Seventy male mice were randomly divided into seven groups ( n = 10). Diabetes was experimentally induced by STZ (60 mg/kg bw). A . saralicum ethanolic extract with doses 5, 20, 80, and 320 mg/kg was administrated for 20 consecutive days in diabetic animals. Based on the obtained results, the untreated diabetic mice showed high blood glucose level, cholesterol, low‐density lipoprotein (LDL), white blood cells count (WBC), and platelets, as well as liver enzymes, urea, and creatinine. Administration of different doses of A . saralicum extract significantly reduced blood glucose level similar to glibenclamide. Also, the levels of catalase and superoxide dismutase enzymes restored toward normal level. All hepatic and renal function parameters as well as hematological parameters were improved following treatment with A . saralicum extract particularly at high doses. Histopathological studies showed a decrease in hepatic, renal, and pancreatic damage after treatment with A . saralicum extract. The results of the present work indicate that A . saralicum ethanolic extract can attenuate diabetic hepato‐renal, pancreatic, and hematological damages.