Open AccessSudachi peel extract powder including the polymethoxylated flavone sudachitin improves visceral fat content in individuals at risk for developing diabetes
Author(s) -
Shikishima Yasuhiro,
Tsutsumi Rie,
Kawakami Ayuka,
Miura Hiroyuki,
Nii Yoshitaka,
Sakaue Hiroshi
Publication year - 2021
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2339
Subject(s) - medicine , hyperlipidemia , placebo , diabetes mellitus , glycemic , lipid profile , waist , randomized controlled trial , obesity , visceral fat , metabolic syndrome , type 2 diabetes , gastroenterology , endocrinology , insulin resistance , pathology , alternative medicine
In vitro and animal studies have indicated that extracts from the peel of the Japanese Citrus sudachi , including sudachitin, ameliorate hyperlipidemia and reduce obesity. Sudachitin, a polymethoxylated flavone, has been reported as having favorable effects on lipid and glucose metabolism but results from clinical trials have been inconsistent. The aim of this study was to determine the effect of consuming capsules of sudachi peel extract powder on visceral fat in Japanese men and women in a randomized controlled trial. This was a 12‐week randomized, double‐blind, placebo‐controlled trial involving 41 participants aged 30–65 years with BMI 23–30 kg/m 2 , randomly allocated to receive either sudachi peel extract powder (sudachitin 4.9 mg/day, n = 21) or placebo ( n = 20) of identical appearance. The primary outcome measure was visceral fat mass, assessed during intervention. Thirty‐eight of the 41 subjects completed the protocol. Compared with placebo, sudachi peel extract powder significantly reduced the ratio of visceral fat to subcutaneous fat, and moderately reduced waist circumference, a metabolic syndrome marker. Glycemic control and lipid profile were not changed significantly in these subjects. Consumption of capsules of sudachi peel extract powder favorably improves the ratio of visceral fat to subcutaneous fat in individuals at risk for developing diabetes, especially in individuals with large visceral fat area, while not adversely affecting glycemic control.