Open AccessCerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
Author(s) -
Zhu Lin,
Liu Yingjuan,
Wu Xiaolin,
Ren Yuqian,
Zhang Qinghua,
Ren Leiming,
Guo Yunliang
Publication year - 2021
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2333
Subject(s) - senescence , neuroprotection , hydrolysate , telomerase , apoptosis , in vivo , chemistry , microbiology and biotechnology , stat3 , cell , biology , biochemistry , pharmacology , hydrolysis , gene
Cerebroprotein hydrolysate‐I (CH‐I)a mixture of peptides extracted from porcine brain tissuehas shown a neuroprotective effect, but its role in brain senescence is unclear. In the present study, we established a senescence model of PC12 cells and mice to investigate the effect of CH‐I on brain senescence via JAK2/STAT3 pathway. The results showed that CH‐I could improve cell viability, inhibit the apoptosis of cells, and reduce the senescence‐positive cells induced by D‐galactose. In vivo , CH‐I improved the learning ability and memory of aging mice, reduced neuronal damage in mice hippocampus. Mechanism studies showed that CH‐I could adjust BDNF protein expressions, activate JAK2/STAT3 pathway, and finally enhance telomerase activity. All these findings indicated that CH‐I showed a neuroprotective effect against brain senescence. These results might provide further reference and support for the application of CH‐I in delaying aging.