Open AccessIn vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
Author(s) -
Shi Qiankun,
Wang Xinya,
Tang Xudong,
Zhen Nuo,
Wang Yupeng,
Luo Zhijian,
Zhang Hao,
Liu Jingsheng,
Zhou Dongfang,
Huang Keke
Publication year - 2021
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2302
Subject(s) - resveratrol , chemistry , antioxidant , abts , in vitro , dispersity , ic50 , pharmacology , biochemistry , food science , dpph , organic chemistry , medicine
Resveratrol (RES) loaded Zein‐SHA (low‐molecular‐weight sodium hyaluronate) nanoparticles with average diameter of about 152.13 nm and polydispersity index (PDI) of 0.122, which can be used to encapsulate, protect and deliver resveratrol. By measuring ABTS free radical scavenging ability and iron (III) reducing power, it was determined that encapsulated resveratrol has higher in vitro antioxidant activity than free resveratrol. When tested with murine breast cancer cells 4T1, the encapsulated resveratrol also showed higher antiproliferative activity than free resveratrol, with IC 50 values of 14.73 and 17.84 μg/ml, respectively. The colloidal form of resveratrol developed in this research may be particularly suitable for functional foods and beverages, as well as dietary supplements and pharmaceutical products.