Open AccessAgar oligosaccharides ameliorate the intestinal inflammation of male Drosophila melanogaster via modulating the microbiota, and immune and cell autophagy
Author(s) -
Ma Chao,
Wang Yifan,
Zhang Guocai,
Dai Xianjun
Publication year - 2021
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.2108
Subject(s) - autophagy , biology , midgut , drosophila melanogaster , immune system , microbiology and biotechnology , inflammation , prebiotic , biochemistry , gene , immunology , apoptosis , larva , botany
Agar oligosaccharide (AOS) is a marine prebiotic with apparent improving health and longevity effects. In this study, the protective effect of AOS on the intestine was evaluated in the sodium dodecyl sulfate (SDS)‐induced inflammatory model of male Drosophila . The results showed that AOS used as a nutritional additive in basal food could lengthen the life of SDS‐stimulated male Drosophila . Additionally, AOS could alleviate the injuries of SDS to microvilli and mitochondria in male Drosophila midgut epithelial cells. AOS could regulate the relative gene expressions in the antibacterial peptides (AMPs), mTOR pathway and autophagy process, and significantly improved the α‐diversity of midgut microbiota and decreased the abundance of Klebsiella aerogenes, a kind of bacteria easily causing infections. Collectively, AOS could ameliorate the intestinal inflammation by modulating the microbiota, and the gene expression of immune and cell autophagy.