Open AccessHigh‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats
Author(s) -
Oliveira Neves Viviano Gomes,
Oliveira Daiane Teixeira,
Oliveira Deborah Campos,
Oliveira Perucci Luiza,
Santos Talita Adriana Pereira,
Costa Fernandes Isabela,
Sousa Graziele Galdino,
Barboza Natália Rocha,
GuerraSá Renata
Publication year - 2020
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.1842
Subject(s) - gut flora , biology , bacteroidetes , firmicutes , food science , feces , lactobacillus , obesity , bacteria , microbiology and biotechnology , endocrinology , 16s ribosomal rna , biochemistry , fermentation , genetics
This study aims to evaluate the effect of long‐term high‐sugar diet (HSD) intake and regular physical activity on gut microbiota as well as its health impact. Weaned male Wistar rats were fed with standard chow diet (SSD) or HSD ad libitum and subjected or not to regular swimming training with a workload (2% of body weight) for 15 weeks. Feces samples were used on microbiome analysis using 16S rRNA amplicon sequencing. HSD increased body mass, adipose cushions, and the serum levels of triglycerides and VLDL, also changed the bacteria taxons associated with metabolic disorders (increase taxons belonging to Proteobacteria phylum and decrease Pediococcus genus); the swim training reverted these changes. SSD intake increased the abundance of bacteria associated with metabolization of dietary fiber. Training in association with SSD consumption beneficially modulated the microbiota, increasing the Bacteroidetes, Bacteroidaceae, Porphyromonadaceae, Parabacteroides , and Lactobacillaceae, and decreasing the Firmicute/Bacteroidetes ratio; training was not able to maintain this profile in animals SHD‐fed. Physical training modulates the gut microbiota reversing the obesogenic response caused by SHD. However, training itself is not efficient for up‐regulating the probiotic bacteria in comparison to its association with a balanced diet.