Open AccessOligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
Author(s) -
Wang Yueming,
Xiong Yanlei,
Zhang Aiping,
Zhao Nannan,
Zhang Jiashen,
Zhao Dongmei,
Yu Zhenhai,
Xu Ning,
Yin Yancun,
Luan Xiying,
Xiong Yanlian
Publication year - 2020
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.1681
Subject(s) - oxidative stress , antioxidant , downregulation and upregulation , chemistry , liver injury , signal transduction , pharmacology , inflammation , biochemistry , medicine , gene
Chitosan oligosaccharide (COS) is the depolymerized product of chitosan possessing various biological activities and protective effects against inflammation and oxidative injury. The aim of the present study was to investigate the antioxidant effects of COS supplements on aging‐related liver dysfunction. We found that COS treatment significantly attenuated elevated liver function biomarkers and oxidative stress biomarkers and decreased antioxidative enzyme activities in liver tissues in D‐galactose (D‐gal)‐treated mice. Furthermore, COS treatment significantly upregulated the expression of Nrf2 and its downstream target genes HO‐1, NQO1, and CAT. Moreover, in vitro experiments showed that COS treatment played a vital role in protecting H 2 O 2 ‐exposed L02 cells against oxidative stress by activating Nrf2 antioxidant signaling. These data indicate that COS could protect against D‐gal‐induced hepatic aging by activating Nrf2 antioxidant signaling, which may provide novel applications for the prevention and treatment of aging‐related hepatic dysfunction.