Open AccessPolyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
Author(s) -
Rahman Md. Mizanur,
Ferdous Khandoker Usran,
Roy Shraboni,
Nitul Iffat Ara,
Mamun Fariha,
Hossain Md. Hemayet,
Subhan Nusrat,
Alam Md Ashraful,
Haque Md. Areeful
Publication year - 2020
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.1640
Subject(s) - uric acid , oxidative stress , malondialdehyde , kidney , nitric oxide , creatinine , antioxidant , polyphenol , chemistry , medicine , food science , pharmacology , biochemistry
Abstract Amla ( Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective effect of amla fruit powder (2.5% W/W) supplementation in kidneys of 2K1C rats. 2K1C rats increased the remnant kidney wet weight and also increased plasma creatinine and uric acid concentration compared to the control. Amla supplementation ameliorates elevated creatinine and uric acid concentration in plasma of 2K1C rats. Various oxidative stress indicators such as malondialdehyde, nitric oxide (NO), and advanced protein oxidation product (APOP) were also increased in plasma, heart, and kidney tissues in 2K1C rats that were also significantly brought down to normal level by amla supplementation. Moreover, the inflammatory cells entry and fibrosis in the 2K1C rat's tissues were prevented by amla supplementation. These research results suggest that amla may restore plasma antioxidant capacities and prevents oxidative stress, inflammation, and fibrosis in 2K1C rats. Taken these results as a base, clinical supplementation of dried amla powder in diet or juice to the CKD patients would be beneficial.