Open AccessChemical composition of cold‐pressed blackberry seed flour extract and its potential health‐beneficial properties
Author(s) -
Choe Uyory,
Li Yanfang,
Yu Lu,
Gao Boyan,
Wang Thomas T. Y.,
Sun Jianghao,
Chen Pei,
Yu Liangli
Publication year - 2020
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.1410
Subject(s) - lncap , food science , polyphenol , abts , trolox , phytochemical , health benefits , chemistry , ellagic acid , composition (language) , lactic acid , antioxidant , biology , traditional medicine , antioxidant capacity , prostate cancer , bacteria , biochemistry , dpph , cancer , medicine , genetics , linguistics , philosophy
The blackberry seed flour was cold‐extracted using 50% acetone and examined for its phytochemical composition and health‐beneficial properties including in vitro gut microbiota modulatory, free radical scavenging, anti‐inflammatory, and antiproliferative capacities. Among identified thirteen components of blackberry seed flour extract through UHPLC‐MS analysis, sanguiin H6 was the primary component and followed by ellagic acid and pedunculagin. For health‐beneficial properties, the blackberry seed flour extract increased the total number of gut bacteria and shifted the abundance of specific bacterial phylum, family, or genus. The extract had RDSC, ORAC, HOSC, and ABTS •+ scavenging capacities of 362, 304, 2,531, and 267 μmol Trolox equivalents (TE)/g, respectively. In addition, the blackberry seed flour extract showed capacities for anti‐inflammation and antiproliferation by suppressing LPS induced IL‐1β mRNA expressions in the cultured J774A.1 mouse macrophages and the proliferation of LNCaP prostate cancer cells. The results suggest potential health benefits and further utilization of blackberry seed flour as functional foods.