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Application of Chimera grid to modelling cell motion and aggregation in a narrow tube
Author(s) -
Chung B.,
Johnson P. C.,
Popel A. S.
Publication year - 2006
Publication title -
international journal for numerical methods in fluids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 112
eISSN - 1097-0363
pISSN - 0271-2091
DOI - 10.1002/fld.1251
Subject(s) - microvessel , chimera (genetics) , ellipsoid , grid , mechanics , computer science , computational fluid dynamics , physics , geometry , mathematics , chemistry , biology , biochemistry , immunohistochemistry , astronomy , immunology , gene
Abstract A computational scheme using the Chimera grid method is presented for simulation of three‐dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid‐filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three‐dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network. Copyright © 2006 John Wiley & Sons, Ltd.