Open AccessEffects of complex extracts of traditional Chinese herbs on gastric mucosal injury in rats and potential underlying mechanism
Author(s) -
Yuan Erdong,
Liu Liangyun,
Huang Min,
Chang Bo,
Qi Chunli,
Gou Na,
Ren Jiaoyan
Publication year - 2021
Publication title -
food frontiers
Language(s) - English
Resource type - Journals
ISSN - 2643-8429
DOI - 10.1002/fft2.73
Subject(s) - ulcer index , astragalus , pharmacology , traditional medicine , acetic acid , gastric mucosa , radix (gastropod) , ethanol , medicine , chemistry , traditional chinese medicine , gastroenterology , stomach , biochemistry , pathology , biology , botany , alternative medicine
Five complex extracts (CEs) of seven Chinese herbs ( Astragalus , Poria cocos , Alpinia officinarum Hance , Radix Puerariae , Ginseng , Licorice , Hericium erinaceus ) were prepared by hot water extraction and evaluated for their effect on gastric ulcer in rats. In rats with acetic acid‐induced chronic gastric ulcer, gross and microscopic appearance showed that gastric mucosal injury index and lesion inhibition rate were improved after CEs gavage for 21 days. Pretreatment with CEs for 21 days in rats with acute gastric ulcer could also improve the gastric mucosal injury by ethanol. CE1, CE4, and CE5 showed more obvious effect in two models. The cell experiments results showed that CE1, CE4, and CE5 effectively inhibited Wnt signaling activity. Thus, they could protect gastric mucosa through inhibiting Wnt signaling pathway. These results indicated that CE1, CE4, and CE5 had significant protective effects on gastric mucosal injury by inhibiting Wnt signalling pathway and could be developed into safe functional products.