Open AccessThe intervention of caffeamide derivative K36 from intestine to brain
Author(s) -
Wang ChinKun
Publication year - 2020
Publication title -
food frontiers
Language(s) - English
Resource type - Journals
ISSN - 2643-8429
DOI - 10.1002/fft2.2
Subject(s) - morris water navigation task , streptozotocin , hippocampus , diabetes mellitus , medicine , endocrinology , neurodegeneration , amyloid beta , inflammation , disease
Caffeic acidphenethyl ester, a strong antioxidant isolated from propolis and its modified derivative K36 show antioxidation, anti‐hyperglycemia, anti‐neuro inflammation, anti‐inflammation, and strong suppression on Helicobacter pylori infection by interrupting the adhesion of H. pylor i to epithelial cells. Two weeks old male Wistar rats were fed high fat diet (HFD, 60% of total calorie) and streptozotocin (STZ, 30 mg/kg body weight) to induce cognition impairment and type 2 diabetes mellitus (T2DM) in rats. K36 (15 mg/ kg body weight) was used to evaluate its effect on brain functions, and pioglitazone (PIO,30mg/g body weight) was used as the positive control. After 13 weeks of intervention, all rats went through passive avoidance test and Morris water maze, and then the beta‐amyloid protein expression in the cortex and hippocampus were determined. Results clearly showed that K36 and PIO decreased the swimming time of diabetes mellitus (DM) rats in the Morris Water Maze. The beta‐amyloid expression in cortex and hippocampus was greatly suppressed by PIO and K36 as compared with the DM group. All results show that K36 is able to pass through a blood–brain barrier and exerts ameliorative effect on cognition impairment in HFD/STZ‐induced T2DM rats. In conclusion, K36 exhibits health benefits on modulating intestine and brain functions. Further studies on autism and other related neurodegeneration diseases are required.