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Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters
Author(s) -
Zhang LuLu,
Yang ZiYu,
Ren JingNan,
Fan Gang,
Pan SiYi
Publication year - 2019
Publication title -
flavour and fragrance journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.393
H-Index - 70
eISSN - 1099-1026
pISSN - 0882-5734
DOI - 10.1002/ffj.3497
Subject(s) - chemistry , reserpine , behavioural despair test , open field , serotonergic , monoamine neurotransmitter , pharmacology , antidepressant , catalepsy , serotonin , dopamine , endocrinology , biochemistry , receptor , medicine , haloperidol , hippocampus
This study was intended to examine the effects of navel orange ( Citrus sinensis (L.) Osbeck) essential oil ( OEO ) on depression in the reserpine‐treated mice. And the chemical composition of OEO was analysed by gas chromatography ( GC ) analysis. The results indicated that the major compounds of OEO were terpenes. And OEO treatment produced an antidepressant‐like effect in mice, as indicated by the increased locomotor activity in the open field test ( OFT ) and attenuated dyslipidemia, but it had no effect on duration of immobility in the forced swim test ( FST ). Dietary OEO counteracted the reserpine‐induced hypothermia and palpebral ptosis. Moreover, OEO treatment increased the levels of serotonin (5‐ HT ) and dopamine ( DA ) in the mice brain. These antidepressant‐like effects of OEO are essentially similar to the effects of the antidepressant fluoxetine. And the action of OEO may be mediated by the central serotonergic and dopaminergic systems.