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Anxiolytic‐like effects of essential oil from Thymus vulgaris was increased during stress
Author(s) -
Satou Tadaaki,
Hayakawa Mako,
Goto Yumi,
Masuo Yoshinori,
Koike Kazuo
Publication year - 2018
Publication title -
flavour and fragrance journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.393
H-Index - 70
eISSN - 1099-1026
pISSN - 0882-5734
DOI - 10.1002/ffj.3434
Subject(s) - chemistry , anxiolytic , elevated plus maze , saline , endocrinology , medicine , blood–brain barrier , pharmacology , intraperitoneal injection , anxiety , central nervous system , psychology , biochemistry , receptor , psychiatry
There is known to be a close relationship among anxiety, fatigue and stress. Here, we studied the anxiolytic‐like effects of essential oil from Thymus vulgaris ( EOT ), while focusing on the relationship with stress. Male ICR mice inhaled (i.h.) EOT for 90 min. Mice were placed under three different conditions; isolated, intraperitoneal (i.p.) administration of saline or polyinosinic‐polycytidylic acid (poly I:C). EOT did not show any significant anxiolytic‐like effects in isolated mice. On the other hand, in brain fatigue model mice by poly I:C, EOT showed significant anxiolytic‐like effects. EOT increased the absolute value in the elevated plus maze ( EPM ) tests in the brain fatigue model mice, while linalool and terpinen‐4‐ol in the brain with poly I:C were elevated when compared with isolated mice. Augmented concentrations of these components in the brain were also observed in mice with saline, i.p. These results suggest that the amount of volatile compounds transferred to the brain increased due to stress or inflammation. In the future, further investigation concerning the relationship between the blood brain barrier ( BBB ) and respiration is required.