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Evaluation of the anti‐inflammatory and antinociceptive effects of myrtenol, a plant‐derived monoterpene alcohol, in mice
Author(s) -
Silva Renan O.,
Salvadori Mirian S.,
Sousa Francisca Beatriz M.,
Santos Maisa S.,
Carvalho Nathalia S.,
Sousa Damião P.,
Gomes Bruno S.,
Oliveira Francisco A.,
Barbosa André Luiz R.,
Freitas Rivelilson M.,
Almeida Reinaldo Nóbrega,
Medeiros JandVenes R.
Publication year - 2014
Publication title -
flavour and fragrance journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.393
H-Index - 70
eISSN - 1099-1026
pISSN - 0882-5734
DOI - 10.1002/ffj.3195
Subject(s) - chemistry , pharmacology , myeloperoxidase , histamine , capsaicin , licking , carrageenan , anti inflammatory , biochemistry , inflammation , immunology , receptor , medicine , biology
Inflammation is characterized by vasodilatation, increase of blood flow and vascular permeability, migration of leucocytes to the inflammatory site, and production of cytokines. The aim of this study was evaluate the anti‐inflammatory and antinociceptive effects of (−)‐myrtenol, a plant‐derived monoterpene alcohol, in mice and its possible mechanisms. Myrtenol was used in classical models of inflammation (paw oedema induced by different agents, carrageenan‐induced peritonitis, myeloperoxidase levels and cytokine measurement) and nociception (acetic acid‐induced writhing, hot‐plate test, and paw licking induced by formalin, glutamate, and capsaicin). Pretreatment with myrtenol effectively inhibited paw oedema induced by carrageenan, compound 48/80, histamine, serotonin and prostaglandin E 2 . Myrtenol also reduced the cell counts, myeloperoxidase activity and cytokine levels (interleukin 1β, but not tumour necrosis factor‐α) of the peritoneal cavity induced by carrageenan. In addition, myrtenol inhibited acetic acid‐induced writhing, did not significantly prolong the latency time in the hot‐plate test, decreased licking time caused by an intraplantar injection of formalin (only in the second phase), glutamate and capsaicin. Myrtenol reduces the inflammatory response and nociception in mice due to the inhibition of the release of inflammatory mediators, cell migration and also to the signalling pathway of receptors involved in the transmission of pain. Copyright © 2014 John Wiley & Sons, Ltd.