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Composition and antituberculosis activity of the volatile oil of Heliotropium indicum Linn. growing in Phitsanulok, Thailand
Author(s) -
Machan Theeraphan,
Korth John,
Liawruangrath Boonsom,
Liawruangrath Saisunee,
Pyne Stephen G.
Publication year - 2006
Publication title -
flavour and fragrance journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.393
H-Index - 70
eISSN - 1099-1026
pISSN - 0882-5734
DOI - 10.1002/ffj.1577
Subject(s) - chemistry , essential oil , chromatography , linalool , gas chromatography , steam distillation , gas chromatography–mass spectrometry , monoterpene , mass spectrometry , traditional medicine , organic chemistry , medicine
Abstract The volatile oil from the aerial parts of H. indicum was isolated by hydrodistillation and analysed by a combination of gas chromatography (GC–FID) and gas chromatography–mass spectrometry (GC–MS). The essential oil was obtained in 0.004% yield as a light brown liquid. The major constituents of the volatile oil of H. indicum were phytol (49.1%), 1‐dodecanol (6.4%) and β ‐linalool (3.0%). In addition, the volatile oil showed significant antituberculosis activity against Mycobacterium tuberculosis H37Ra in the Alamar blue assay system with an MIC of 20.8 µg/ml. Copyright © 2005 John Wiley & Sons, Ltd.