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Scale‐up of analytical chromatography to the simulated moving bed separation of the enantiomers of the flavour norterpenoids α‐ionone and α‐damascone
Author(s) -
Zei Gianmarco,
Quattrini Francesca,
Mazzotti Marco,
Fuganti Claudio,
Morbidelli Massimo
Publication year - 2002
Publication title -
flavour and fragrance journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.393
H-Index - 70
eISSN - 1099-1026
pISSN - 0882-5734
DOI - 10.1002/ffj.1088
Subject(s) - chemistry , enantiomer , ionone , simulated moving bed , chromatography , flavour , cyclodextrin , high performance liquid chromatography , chiral stationary phase , organic chemistry , adsorption , food science
The scale‐up of the HPLC separation of the enantiomers of the flavour norterpenoid ketones α‐ionone and α‐damascone from analytical to preparative scale was achieved using the chromatographic simulated moving bed (SMB) technique. Commercial HPLC columns, with heptakis‐(2,3,6‐per‐ O ‐methyl)‐β‐cyclodextrin bound to silica gel as chiral stationary phase, were employed for the separation. High‐purity enantiomers of both chiral compounds have been obtained with a rather satisfactory productivity. Copyright © 2002 John Wiley & Sons, Ltd.