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Mutagenicity of trinitrotoluene and metabolites formed during anaerobic degradation by Clostridium acetobutylicum ATCC 824
Author(s) -
Padda Ranjit S.,
Wang Chuan Yue,
Hughes Joseph B.,
Bennett George N.
Publication year - 2000
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620191203
Subject(s) - trinitrotoluene , hydroxylamine , chemistry , clostridium acetobutylicum , biotransformation , anaerobic exercise , degradation (telecommunications) , derivative (finance) , clostridium , salmonella , biodegradation , environmental chemistry , organic chemistry , microbiology and biotechnology , bacteria , biology , ethanol , enzyme , explosive material , butanol , physiology , telecommunications , computer science , financial economics , economics , genetics
2, 4, 6‐Trinitrotoluene (TNT) and its metabolites formed during anaerobic degradation are mutagenic in Salmonella typhimurium TA98 and TA100 when checked in the absence of rat liver activation system (S9). The monohydroxylamino derivatives that are formed as first‐step intermediates of the pathway are less mutagenic than TNT, but the dihydroxylamino derivative that is the second intermediate is much more mutagenic than the parent compound. Whereas TNT is very stable under aerobic as well as anaerobic conditions, the hydroxylamine derivatives are not. The dihydroxylamino derivative of TNT that is the most mutagenic is less stable compared with the monohydroxylamino derivatives of TNT.