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Evaluation of the annual killifish Nothobranchius guentheri as a tool for rapid acute toxicity screening
Author(s) -
Shedd, Tommy R.,
Widder Mark W.,
Toussaint Margaret W.,
Sunkel Mark C.,
Hull Eugene
Publication year - 1999
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620181020
Subject(s) - killifish , biology , acute toxicity , toxicology , toxicity , zoology , fishery , fish <actinopterygii> , medicine
This study evaluated the use of Nothobranchius guentheri as a novel organism for rapid acute toxicity screening. A major advantage of the species is that there is no need to maintain a continuous culture to have organisms immediately available for testing. Rather, the embryos are viable under long—term storage conditions and can be hatched within a few hours. The tests require only 24 h with standard laboratory equipment. Sensitivity levels for 11 representative toxicants were comparable to those reported for five of the standard U.S. Environmental Protection Agency test species requiring continuous culture.