Premium
Metal toxicity in two rodent species and redox potential: Evaluation of quantitative structure—activity relationships
Author(s) -
Lewis, David F.V.,
Dobrota Miloslav,
Taylor Marina G.,
Parke Dennis V.
Publication year - 1999
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620181012
Subject(s) - chemistry , toxicity , metal , polarizability , redox , acute toxicity , metal toxicity , barium , metal ions in aqueous solution , ionic radius , inorganic chemistry , environmental chemistry , ion , organic chemistry , molecule
A quantitative structure—activity relationship study of acute toxicity in the mouse and rat is described for the soluble salts of a relatively large number of metals (between 25 and 30 in total). Electrode potential is the major determinant of acute metal toxicity ( R = 0.85 and 0.86) for an intraperitoneal dose in the mouse, whereas the addition of ionic radius and polarizability enables the inclusion of notable outliers in the original expression, such as beryllium and barium, thus giving a good correlation ( R = 0.87) with toxicity for 27 metal compounds. These findings are rationalized on the basis of relative ease of ionization, electron affinity, and transport factors of the metals and their ions, thus being consistent with the hard and soft acids and bases properties of metals and their biological reactivities.