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Interrenal dysfunction in fish from contaminated sites: In vivo and in vitro assessment
Author(s) -
Hontela Alice
Publication year - 1998
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620170107
Subject(s) - esox , pike , pollutant , in vivo , stressor , endocrine system , biology , perch , environmental chemistry , biomonitoring , adrenocorticotropic hormone , bioaccumulation , hormone , ecotoxicology , physiology , medicine , toxicology , endocrinology , chemistry , fish <actinopterygii> , ecology , fishery , microbiology and biotechnology , neuroscience
Cortisol, synthesized in the interrenal cells of teleost head kidney, has a major role in the physiologic response to physical and chemical stressors. Plasma levels of cortisol increase in physiologically competent fish acutely exposed to stressors such as cadmium or mercury. The effects of chronic low level exposures are less well understood. We have diagnosed an endocrine impairment characterized by a reduced capacity to elevate plasma cortisol levels in response to an acute standardized capture stress in yellow perch ( Perca flavescens ) and in northern pike ( Esox lucius ) sampled at sites contaminated by mixtures of pollutants (heavy metals, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls), by heavy metals, or by bleached kraft mill effluent. Our studies with fish, as well as with amphibians at contaminated sites, demonstrated that low level chronic exposures impair secretion of corticosteroids. We have developed new tests for assessment of the functional integrity of teleost and amphibian interrenal tissue by using an adrenocorticotropic hormone (ACTH) challenge, in vivo and in vitro. The reduced ability to respond to ACTH indicates that the normal neuroendocrine response to stressors may be disrupted and that the ability to cope with biotic and abiotic stressors in the environment may be significantly reduced in the impaired animals.