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Effects of acute 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin exposure on plasma thyroid and sex steroid hormone concentrations and estrogen receptor levels in adult great blue herons
Author(s) -
Janz David M.,
Bellward Gail D.
Publication year - 1997
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620160517
Subject(s) - endocrinology , medicine , estrogen , tetrachlorodibenzo p dioxin , testosterone (patch) , hormone , chemistry , thyroid , body weight , estrogen receptor , toxicity , biology , cancer , breast cancer
Adult great blue herons ( Ardea herodias ) were exposed intraperitoneally to a single dose of 20 μg/kg body weight of 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) and sacrificed after 14 d. Approximately 1.9% of the total TCDD dose was measured in the liver. No differences were found in liver weight or liver to body weight ratio between control and TCDD‐treated birds. Hepatic microsomal ethoxyresorufin O ‐deethylase (EROD) activity was induced sixfold above control activities in TCDD‐exposed herons ( p < 0.001). Plasma total T 4 concentration was significantly elevated in TCDD‐exposed herons ( p < 0.05). The TCDD treatment had no effect on plasma total T 3 levels, or on the plasma T 3 to T 4 ratio. No effect of this TCDD exposure was found on plasma 17β‐estradiol or testosterone concentrations, or on hepatic estrogen receptor affinities and concentrations is male or female herons.