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A method for evaluating the toxicity of industrial solvent mixtures
Author(s) -
Kon Douglas W.,
Gorski Robert A.
Publication year - 1997
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620160515
Subject(s) - toluene , toxicity , xylene , solvent , toxicology , chromatography , chemistry , developmental toxicity , logistic regression , environmental chemistry , biology , organic chemistry , medicine , fetus , genetics , pregnancy
The toxicity of a mixture of toluene and mixed xylenes was studied with the frog embryo teratogenesis assay— Xenopus (FETAX). Single compound experiments with either toluene or mixed xylenes show that growth inhibition, not mortality or malformation, is the most sensitive toxic endpoint in the FETAX system (i.e., growth is inhibited at lower exposure concentrations than those resulting in malformations and mortality). A multiple logistic regression analysis model described mortality and malformation as functions of exposure concentrations of toluene and mixed xylenes. The results indicate that toluene and mixed xylenes are additive in their effects on mortality in the FETAX system. Further experimentation is necessary to validate the model's ability to describe malformation as a function of coexposure to toluene and mixed xylenes.