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Predicting relative toxicity and interactions of divalent metal ions: Microtox® bioluminescence assay
Author(s) -
Newman Michael C.,
McCloskey John T.
Publication year - 1996
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620150308
Subject(s) - chemistry , metal , divalent , ion , metal ions in aqueous solution , inorganic chemistry , stability constants of complexes , organic chemistry
Both relative toxicity and interactions between paired metal ions were predicted with least‐squares linear regression and various ion characteristics. Microtoxr̀ 15 min EC50s (expressed as free ion) for Ca(II), Cd(II), Cu(II), Hg(II), Mg(II), Mn(II), Ni(II), Pb(II), and Zn(II) were most effectively modeled with the constant for the first hydrolysis ( K H for M n + + H 2 O → MOH n ‐1 + H + ) although other ion characteristics were also significant in regression models. The [log K H ] is correlated with metal ion affinity to intermediate ligands such as many biochemical functional groups with O donor atoms. Further, ordination of metals according to ion characteristics, e.g., [log K H ], facilitated prediction of paired metal interactions. Pairing metals with strong tendencies to complex with intermediate or soft ligands such as those with O or S donor atoms resulted in strong interactions.