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Uptake, distribution and elimination of 54 Mn(II) in the brown trout ( Salmo trutta )
Author(s) -
Rouleau Claude,
Tjälve Hans,
Gottofrey James,
Pelletier ÉMilien
Publication year - 1995
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620140318
Subject(s) - salmo , gill , trout , mucus , brown trout , kidney , chemistry , manganese , medicine , biology , toxicokinetics , zoology , anatomy , endocrinology , metabolism , fish <actinopterygii> , ecology , fishery , organic chemistry
Abstract Brown trout ( Salmo trutta ) were exposed to water containing 0.1 μg·L −1 (1.8 nmol·L −1 ) of 54 Mn(II) for 1, 3, or 6 weeks. Additional trout were exposed for 3 weeks and allowed to depurate for 1 or 3 weeks. Both the uptake and the organ distribution of manganese (Mn) were determined by gamma counting and whole‐body autoradiography. Steady‐state concentration, C ss , and biological half‐life, t 1/2 , were calculated. The whole‐body Mn concentration (1.78 μg·kg −1 ) reached after 6 weeks of exposure was close to C ss (1.88 μg·kg −1 ) and t 1/2 was 9.6 d. Manganese concentration in tissues followed the decreasing order liver > viscera without liver and kidney > gills > skin, fins, bones, and head excluding gills, brain, and eyes > kidney ≈ epidermal mucus > brain > eyes > muscle. Autoradiograms indicated high Mn concentrations in the pancreatic tissue, skeleton, gastrointestinal mucosa, and olfactory system. Gills, viscera, and eyes ( t 1/2 = 3.7 to 8.8 d) were near steady state after 6 weeks of exposure, while the other tissues were not ( t 1/2 = 14.6 to 26.4 d). The depuration rate of total radioactivity was relatively rapid initially as 22% of Mn content was lost during the first week, and became slower in the following 2 weeks. Participation of Mn in enzymatic activities of liver, pancreas, and gastrointestinal mucosa may explain its high uptake in these tissues, whereas accumulation in the skeleton seems to be related to bone formation. The uptake of Mn by way of olfactory system favoured its accumulation in the brain of trout. As Mn is known to be neurotoxic, we suggest this route of uptake could be of toxicological significance for fish.