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Congener‐specific biotransformation and bioaccumulation of PCDDs and PCDFs from fly ash in fish
Author(s) -
Sijm Dick T. H. M.,
Opperhuizen Antoon,
Wever Han
Publication year - 1993
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620121016
Subject(s) - bioaccumulation , congener , biotransformation , environmental chemistry , chemistry , polychlorinated dibenzofurans , bioconcentration , fish <actinopterygii> , partition coefficient , chlorine atom , toxicokinetics , polychlorinated dibenzodioxins , toxic equivalency factor , persistent organic pollutant , toxicity , pollutant , chromatography , organic chemistry , biology , medicinal chemistry , fishery , enzyme
Biotransformation may be responsible for the lack of bioaccumulation of a number of polychlorinated dibenzo‐ p ‐dioxins (PCDDs) and dibenzofurans (PCDFs). Goldfish ( Carassius auratus ) that were exposed to PCDDs and PCDFs, and piperonylbutoxide (PBO) in water, bio‐concentrated significantly more congeners than goldfish exposed to PCDDs and PCDFs only. Mono‐oxygenase activity, which is responsible for the oxidation of specific PCDD and PCDF congeners in untreated fish, was inhibited by fish treated with PBO. In the PBO‐treated group and in the control group, congeners with all lateral positions substituted were found. Congeners that lack chlorine substitution on one or more of the lateral (2,3,7,8) positions and congeners that have all lateral positions chlorinated were found only in PBO‐treated fish. Congeners that have at least one free lateral position were therefore assumed to be biotransformed. There was no relationship between the octanol/water partition coefficient and biotransformation of the PCDDs and PCDFs. No limitation of uptake for higher chlorinated PCDD and PCDF congeners was found.