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Benzo[ a ]pyrene metabolism and excretion in white suckers with chronic liver diseases
Author(s) -
Smith Ian R.,
Kirby Gordon M.,
Ferguson Hugh W.,
Hayes M. Anthony
Publication year - 1993
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620120514
Subject(s) - glucuronide , benzo(a)pyrene , excretion , glutathione , population , metabolite , metabolism , medicine , chemistry , bile duct , endocrinology , biology , carcinogen , biochemistry , enzyme , environmental health
Wild white suckers ( Catostomus commersoni ) with diseased bile ducts excreted an oral dose of benzo[ a ]pyrene (BaP) into their bile as glucuronide, glutathione, and sulfo‐conjugates at twice the rate (16.76 nmol/h) of an unaffected reference population (7.52 nmol/h). BaP‐hydroxylase (10% higher in the diseased population), glutathione‐ S ‐transferase (similar), or uridine‐5′‐diphos‐phoglucuronic acid transferase (50% lower) levels did not correlate with these excretion rates. Metabolite levels were 57% higher in the liver of affected suckers than those in the liver of reference suckers, which might be due to bile retention within the diseased bile ducts. The bile duct disease affecting white suckers does not appear to restrict the metabolism and excretion of BaP.