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Partial rapid metabolism of 1,2‐dichloroethane by Methylosinus trichosporium OB‐3b
Author(s) -
Riebeth D. M.,
Belser N. O.,
Castro C. E.
Publication year - 1992
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620110407
Subject(s) - chemistry , chloroacetic acid , 1,2 dichloroethane , trichloroethylene , halogen , metabolism , ethylene , organic chemistry , biochemistry , alkyl , catalysis
Resting cell suspensions of the soil methylotroph Methylosinus trichosporium OB‐3b rapidly dehalogenate ethylene dichloride, but the process stops after one halogen is removed. Work with 14 C‐ and 13 C‐labeled 1,2‐dichloroethane shows that the biodehalogenation entails a direct hydrox‐ylation of one of the CCl bonds to produce chloroethanol. The latter is rapidly oxidized to chloroacetic acid. The organism does not metabolize this acid on the time scale of these experiments.