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Uptake and elimination kinetics of organophosphorous pesticides in the guppy (poecilia reticulata) : Correlations with the octanol/water partition coefficient
Author(s) -
de Bruijn Jack,
Hermens Joop
Publication year - 1991
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620100610
Subject(s) - bioconcentration , poecilia , guppy , partition coefficient , chemistry , reaction rate constant , environmental chemistry , toxicokinetics , kinetics , elimination rate constant , pesticide , poeciliidae , biotransformation , octanol , chlorobenzene , fish <actinopterygii> , chromatography , bioaccumulation , organic chemistry , ecology , toxicity , biology , pharmacokinetics , volume of distribution , quantum mechanics , pharmacology , physics , fishery , enzyme , catalysis
Bioconcentration factors, uptake rate constants and elimination rate constants of a series of organophosphorous pesticides were determined in the guppy (Poecilia reticulata). The results of these three toxicokinetic parameters were related to measured octanol/water partition coefficients ( K ow ). A simple one‐compartment model fitted the uptake and elimination characteristics of the chemicals. A biphasic relationship was observed between log k 1 (uptake rate constant) and log K ow , whereas elimination rate constants were inversely related to K ow . For some of the test compounds substantially higher elimination rates were found, compared to isolipophilic chlorobenzenes, which resulted in lower bioconcentration factors. This divergent behavior is discussed in view of possible biotransformation reactions for these compounds.