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Brain cholinesterase activity of bobwhite acutely exposed to chlorpyrifos
Author(s) -
Cairns Michael A.,
Maguire Christine C.,
Williams Bill A.,
Bennett Jewel K.
Publication year - 1991
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620100512
Subject(s) - colinus , chlorpyrifos , bobwhite quail , cholinesterase , toxicology , zoology , biology , pesticide , organophosphate , quail , chemistry , endocrinology , ecology
Northern bobwhite, Colinus virginianus , were orally dosed with the organophosphorus insecticide chlorpyrifos to examine effects on brain chohnesterase (ChE) activity. Two‐week‐old quail were acutely exposed and euthanized at selected times following gavage‐dosing, ranging from I to 120 h later. The ChE activity was determined in treated birds and compared to concurrently tested control (corn oil) birds. It was found that a lag time of 2 to 4 h following exposure was necessary to detect significant ChE depression caused by chlorpyrifos. The lowest dose that produced ChE depression in these tests was between —30 and 50 mg chlorpyrifos/kg body weight, with some mortality occurring at the high end of that range. Depression typically persisted for at least 24 h.