Premium
Inhibition of brain and plasma cholinesterase activity in zebra finches orally dosed with fenitrothion
Author(s) -
Holmes Stephen B.,
Boag Peter T.
Publication year - 1990
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620090308
Subject(s) - cholinesterase , fenitrothion , zebra finch , chemistry , in vivo , zoology , pharmacology , toxicology , biology , pesticide , agronomy , microbiology and biotechnology , neuroscience
Zebra finches (Poephila guttata) were given single oral doses of fenitrothion insecticide dissolved in soya bean oil. Brain and plasma cholinesterase (ChE) activities were measured periodically up to 10 d postexposure. Dosage rates of 1.04, 3.80 and 11.36 mg active ingredient/kg body weight resulted in maximum brain ChE inhibitions of 50, 70 and 75%, and maximum plasma ChE inhibitions of 78, 82 and 89%, respectively. Recovery of ChE activity in vivo followed an exponential pattern, with plasma ChE activity recovering more rapidly than brain ChE activity. At dosage rates of 1.04 and 3.80 mg/kg, plasma ChE activity recovered to normal in 1 to 2 d. Brain ChE activity was inhibited up to 10 d after dosing at 1.04 mg/kg. There was some mortality of exposed birds at the two higher dosage rates. Birds that died exhibited brain ChE inhibitions ranging from 3 to 84%.