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Structure‐Activity for uptake and toxicity of DDT‐type insecticides utilizing an NMR method for estimating σ*
Author(s) -
Coats Joel R.,
Williams John W.,
Chang Carolyn,
Lee AnHorng,
Metcalf Robert L.
Publication year - 1989
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620080106
Subject(s) - substituent , toxicity , toxicology , chemistry , insect , stereochemistry , pharmacology , biology , organic chemistry , ecology
Structure‐activity relationships were examined in toxicological studies with DDT‐type insecticides. The Taft σ* parameter for the electronegative character of substituents correlated well with the uptake of the analogs through insect tarsi and with acute oral toxicities to mice. Substituent groups with stronger electron‐withdrawing capacities penetrated more slowly through the insect cuticle and were markedly more toxic to mice. A nuclear magnetic resonance method was utilized to obtain estimated σ* values for use in the correlations.