Premium
The acute oral LD50 of technical pentachlorophenol in developing rats
Author(s) -
St. Omer Vincent E. V.,
Gadusek Frank
Publication year - 1987
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620060209
Subject(s) - pentachlorophenol , rigor mortis , toxicity , acute toxicity , toxicology , median lethal dose , physiology , medicine , anesthesia , biology , anatomy , ecology
The acute oral LD50s for technical‐grade pentachlorophenol (T‐PCP) were calculated by the Litchfield‐Wilcoxon method during the ontogenetic growth of 10‐ to 134‐d‐old rats. Signs of toxicity included accelerated respiration, hyperpyrexia, collapse, asphyxial convulsions and death followed by rapid rigor mortis. Young rats (not yet weaned, 10 and 20 d old) and adults (70 and 134 d old) were more susceptible to the toxic and lethal effects of T‐PCP than were juveniles (25 to 50 d old). The LD50 (mg/kg) ranged from 50 to 180 for preweaned rats, from 220 to 230 for juveniles and from 80 to 120 for adults.