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Bioconcentration and disposition of 1,3,6,8‐tetrachlorodibenzo‐ p ‐dioxin and octachlorodibenzo‐ p ‐dioxin by rainbow trout and fathead minnows
Author(s) -
Muir D.C.G.,
Yarechewski A.L.,
Knoll A.,
Webster G.R.B.
Publication year - 1986
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5620050305
Subject(s) - rainbow trout , tetrachlorodibenzo p dioxin , pimephales promelas , chemistry , bioconcentration , salmo , metabolite , environmental chemistry , trout , toxicokinetics , toxicity , fish <actinopterygii> , bioaccumulation , fishery , biology , biochemistry , minnow , organic chemistry
Accumulation of 14 C‐labeled 1,3,6,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) and octachlorodibenzo‐ p ‐dioxin (OCDD) from water by rainbow trout fry ( Salmo gairdneri ) and fathead minnows ( Pimephales promelas ) was studied using a 5‐d uptake and 24 to 48‐d depuration period. Average exposure concentrations ranged from 4 to 211 ng/L for 1,3,6,8‐TCDD and from 9 to 415 ng/L for OCDD. Equilibrium bioconcentration factors for total 14 C in fish, calculated by use of a two‐compartment first‐order rate model, were 2,100 and 5,702 for 1,3,6,8‐TCDD in trout fry and minnows, respectively, and 85 and 2,226 for OCDD in the same species. Elimination rates of both isomers were rapid, with half‐lives of 14 C ranging from 6 to 9 d for 1,3,6,8‐TCDD and from 5 to 13 d for OCDD. The highest concentrations of radiolabeled 1,3,6,8‐TCDD and OCDD were found in bile. A metabolite of 1,3,6,8‐TCDD in bile was identified as a conjugate of a hydroxylated tetrachloro‐derivative. Dietary exposure of rainbow trout resulted in low accumulation factors, ranging from 0.034 for OCDD to 0.018 for 1,3,6,8‐TCDD, based on toluene‐extractable radioactivity.