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Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
Author(s) -
Gergs André,
Hager Jutta,
Bruns Eric,
Preuss Thomas G.
Publication year - 2021
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.5027
Subject(s) - toxicodynamics , toxicokinetics , toxicology , lethality , imidacloprid , environmental toxicology , chemistry , biology , environmental chemistry , pharmacology , toxicity , pesticide , ecology , pharmacokinetics , organic chemistry
Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius . Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibition under chronic exposures. The starvation effect is an indirect cause for mortality, which, for the neonicotinoids, adds to the direct/acute mortality, although the results suggests that this additional effect is not relevant for flupyradifurone. Environ Toxicol Chem 2021;40:1706–1712. © 2021 Bayer Inc. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.