Premium
Yolk–Water Partitioning of Neutral Organic Compounds in the Model Organism Danio rerio
Author(s) -
Ulrich Nadin,
Schweiger Nicole,
Pfennigsdorff Andrea,
Scholz Stefan,
Goss KaiUwe
Publication year - 2020
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.4744
Subject(s) - yolk , yolk sac , danio , partition coefficient , chemistry , environmental chemistry , sorption , biotransformation , zebrafish , embryo , chromatography , biology , food science , fishery , biochemistry , organic chemistry , adsorption , gene , enzyme
Abstract Yolk is the most important temporary biological compartment of the early life stages of fish embryos. The sorption strength of a chemical to yolk components may significantly influence the distribution of that chemical in the fish embryo. We determined yolk–water partition coefficients ( K yolk/water , in liters of water per kilogram of yolk, normalized to dry wt) for 70 neutral organic chemicals. The log K yolk/water values range from 0.76 to 6.56. On the basis of these values, we developed polyparameter linear free energy relationship models to predict yolk–water partitioning for a broad range of neutral organic chemicals with a root mean squared error of 0.37 and r 2 of 0.919. These models can be applied for the prediction of internal concentrations at equilibrium (neglecting biotransformation and active transport) in the zebrafish embryo test system. Environ Toxicol Chem 2020;39:1506–1516. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.