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Studies on Toxicity of Suspensions of CdTe Quantum Dots to Biomphalaria glabrata Mollusks
Author(s) -
Vasconcelos Lima Maíra,
Andrade Pereira Maria Isabela,
Cabral Filho Paulo Euzébio,
Nascimento de Siqueira Williams,
Milca Fagundes Silva Hianna Arely,
França Elvis Joacir,
Saegesser Santos Beate,
Mendonça de Albuquerque Melo Ana Maria,
Fontes Adriana
Publication year - 2019
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.4525
Subject(s) - biomphalaria glabrata , quantum dot , toxicity , bioaccumulation , cadmium , hepatopancreas , cytotoxicity , micronucleus test , environmental toxicology , biophysics , nanotoxicology , toxicology , micronucleus , chemistry , nanotechnology , biology , environmental chemistry , zoology , materials science , biochemistry , in vitro , schistosomiasis , organic chemistry , schistosoma mansoni , helminths
Quantum dots have generated great interest because of their optical properties, both to life sciences and electronics applications. However, possible risks to the environment associated with these nanoparticles are still under investigation. The present study aimed to evaluate the toxicity of suspensions of cadmium telluride (CdTe) quantum dots to Biomphalaria glabrata mollusks, a very sensitive aquatic environmental bioindicator for physical and chemical agents. Toxicity was examined by using embryos and adult mollusks as well as hemocytes. The distribution of cadmium in the organs of adults was also assessed. Effects of the stabilizing agent of the quantum dots were also evaluated. Animals were exposed to suspensions of quantum dots for 24 h, at concentrations varying from 1.2 to 20 nM for embryos and from 50 to 400 nM for adult mollusks. Results showed that suspensions of quantum dots induced malformations and mortality in embryos and mortality in adults, depending on the concentration applied. In the cytotoxicity study, hemocyte apoptosis was observed in adults exposed to the highest concentration of quantum dots applied as well as to the stabilizing agent. Cell binucleation and micronucleus frequencies were not significative. Bioaccumulation evaluation revealed that quantum dots targeted the digestive gland (hepatopancreas). Taken together, outcomes suggested that specific nano‐effects related directly not only to composition but also to the aggregation of quantum dots may be mediating the observed toxicity. Thus B. glabrata was determined to be a very sensitive species for interpreting possible nano‐effects in aquatic environments. Environ Toxicol Chem 2019;38:2128–2136. © 2019 SETAC.