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Induction of maxillary and mandibular squamous epithelial cell proliferation in mink ( Neovison vison ) by β‐naphthoflavone
Author(s) -
Matz Danielle K.,
Chuck Joanna,
Hosmer Robin J.,
Piper Hannah C.,
Link Jane E.,
Fitzgerald Scott D.,
Steibel Juan P.,
Bursian Steven J.
Publication year - 2019
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.4329
Subject(s) - mink , aryl hydrocarbon receptor , lesion , aryl hydrocarbon receptor nuclear translocator , biology , chemistry , medicine , pathology , biochemistry , ecology , transcription factor , gene
A jaw lesion reported in mink exposed to 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) and TCDD‐like chemicals is considered a potential indicator of exposure to these chemicals. Many of the effects of TCDD‐like chemicals are induced through interaction with the aryl hydrocarbon receptor. The present study indicates that mink dosed with β‐naphthoflavone, which is an aryl hydrocarbon receptor ligand but not a TCDD‐like chemical, also develop the lesion. Environ Toxicol Chem 2019;38:460–463. © 2018 SETAC