z-logo
Premium
Production of polycyclic aromatic hydrocarbon metabolites from a peroxynitrite/iron(III) porphyrin biomimetic model and their mutagenicities
Author(s) -
Luo Yunjing,
Dai Jing,
Zhong Rugang,
She Yuanbin,
Liu Rui,
Wei Huachen
Publication year - 2011
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.430
Subject(s) - pyrene , peroxynitrite , chemistry , fluoranthene , polycyclic aromatic hydrocarbon , porphyrin , carcinogen , hydrocarbon , nitro , stereochemistry , environmental chemistry , biochemistry , organic chemistry , enzyme , superoxide , alkyl
Some polycyclic aromatic hydrocarbons (PAHs) are typical promutagens that require metabolic activation to exhibit their mutagenicities and carcinogenicities. The metabolites of three PAHs, pyrene (PY), fluoranthene (FLU), and benzo[ a ]pyrene (B a P), produced from the peroxynitrite/T( p ‐Cl)PPFeCl(peroxynitrite/(chloride)iron(III)tetrakis( p ‐chlorophenyl)porphyrin) system, have been identified with high‐performance liquid chromatography coupled with electron spray ionization tandem mass spectrometry. The results demonstrated that three major metabolites were the quinone group, OH group, and nitro group. In the Ames test, all three PAH metabolites became mutagenic without using the enzymatic activating system, whereas their parents did not show positive results. Cell transformation assay indicated that 1,3‐nitro‐B a P and B a P metabolites produced from this biomimetic system have more serious effects in inducing cancer than the B a P parent. Environ. Toxicol. Chem. 2011; 30:723–729. © 2010 SETAC

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here