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Embryonic effects of an environmentally relevant PCB mixture in the domestic chicken
Author(s) -
Ottinger Mary Ann,
Lavoie Emma T.,
Bohan Meredith E.B.,
Marcel Allegra M.,
Tschiffely Anna E.,
Duffy Kara B.,
McKernan Moira,
Thompson Nichola,
Whitehouse H. Kasen,
Davani Kimya,
Strauss Marci,
Tillitt Donald E.,
Lipton Josh,
Dean Karen M.
Publication year - 2018
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.4218
Subject(s) - hatching , congener , biology , pollutant , toxicology , zoology , environmental chemistry , chemistry , ecology
Studies were conducted to develop methods to assess the effects of a complex mixture of polychlorinated biphenyls (PCBs) in the domestic chicken ( Gallus domesticus ). Treatments were administered by egg injection to compare embryonic effects of an environmentally relevant PCB congener mixture in the domestic chicken over a range of doses. Chicken eggs were injected with the PCB mixture with a profile similar to that found in avian eggs collected on the upper Hudson River, New York, USA, at doses that spanned 0 to 98 μg/g egg. Eggs were hatched in the laboratory to ascertain hatching success. In the domestic chicken, the median lethal dose was 0.3 μg/g. These data demonstrate adverse effects of an environmentally relevant PCB mixture and provide the basis for further work using in vitro and other models to characterize the potential risk to avian populations. Environ Toxicol Chem 2018;37:2513–2522. © 2018 SETAC