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An automated approach to Litchfield and Wilcoxon's evaluation of dose–effect experiments using the R package LW1949
Author(s) -
Adams Jean V.,
Slaght Karen S.,
Boogaard Michael A.
Publication year - 2016
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.3490
Subject(s) - wilcoxon signed rank test , statistic , software package , statistics , computer science , mathematics , software , mann–whitney u test , programming language
Abstract The authors developed a package, LW1949, for use with the statistical software R to automatically carry out the manual steps of Litchfield and Wilcoxon's method of evaluating dose–effect experiments. The LW1949 package consistently finds the best fitting dose–effect relation by minimizing the chi‐squared statistic of the observed and expected number of affected individuals and substantially speeds up the line‐fitting process and other calculations that Litchfield and Wilcoxon originally carried out by hand. Environ Toxicol Chem 2016;35:3058–3061. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.