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Relative sensitivities among avian species to individual and mixtures of aryl hydrocarbon receptor–active compounds
Author(s) -
Wei Fenghua,
Li Juanying,
Zhang Rui,
Xia Pu,
Peng Ying,
Giesy John P.,
Zhang Xiaowei
Publication year - 2016
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.3269
Subject(s) - quail , pheasant , phasianus , coturnix japonica , galliformes , aryl hydrocarbon receptor , potency , coturnix , chemistry , polychlorinated dibenzofurans , coturnix coturnix , biology , zoology , biochemistry , environmental chemistry , endocrinology , in vitro , gene , transcription factor
Dioxins and dioxin‐like compounds (DLCs) are potent toxicants to most vertebrates. Sensitivities to DLCs vary among species. In the present study, the sensitivities of avian species (chicken [ Gallus gallus ], ring‐necked pheasant [ Phasianus colchicus ], and Japanese quail [ Coturnix japonica ]) to some polychlorinated dibenzo‐ p ‐dioxins and polychlorinated dibenzofurans (PCDD/Fs) were determined by using species‐specific, in vitro, transactivation assays based on a luciferase reporter gene under control of species‐specific aryl hydrocarbon receptors. In ring‐necked pheasant and Japanese quail, 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) was not the most potent inducer of toxic effects. Especially for Japanese quail, the relative potency values of most of 9 PCDD/Fs tested were greater than for TCDD. The rank order of avian species sensitivities to DLCs was chicken > ring‐necked pheasant > Japanese quail. Effects of binary mixtures of TCDD, 2,3,7,8‐tetrachlorodibenzofuran, and 2,3,4,7,8‐pentachlorodibenzofuran were strictly additive. Moreover, we also found that the primary DLCs that were responsible for most of the potency of the DLC mixtures can be deduced by using ordination in a multidimensional space defined by the avian species sensitivities. Overall, the relative potency and the species sensitivities of these chemicals could guide risk assessments to wild species when exposure to mixtures of DLCs in the environment. Environ Toxicol Chem 2016;35:1239–1246. © 2015 SETAC