Premium
Insights into the nature of uranium target proteins within zebrafish gills after chronic and acute waterborne exposures
Author(s) -
Bucher Guillaume,
Mounicou Sandra,
Simon Olivier,
Floriani Magali,
Lobinski Ryszard,
Frelon Sandrine
Publication year - 2016
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.3249
Subject(s) - gill , zebrafish , fish <actinopterygii> , environmental chemistry , biology , uranium , heavy metals , toxicity , toxicology , chemistry , fishery , biochemistry , materials science , organic chemistry , metallurgy , gene
Abstract New data on the nature of the protein targets of uranium (U) within zebrafish gills were collected after waterborne exposure, with the aim of a better understanding of U toxicity mechanisms. Some common characteristics of the U protein target binding properties were found, such as their role in the regulation of other essential metals and their phosphorus content. In total, 21 potential protein targets, including hemoglobin, are identified and discussed in terms of the literature. Environ Toxicol Chem 2016;35:736–741. © 2015 SETAC