Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish | Zendy

Boyle David | Zendy; Boran Halis | Zendy; Atfield Andrew J. | Zendy; Henry Theodore B. | Zendy

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Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish

Author(s) -

Boyle David,

Boran Halis,

Atfield Andrew J.,

Henry Theodore B.

Publication year - 2015

Publication title -

environmental toxicology and chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 171

eISSN - 1552-8618

pISSN - 0730-7268

DOI - 10.1002/etc.2840

Subject(s) - toxicity , aqueous solution , nanoparticle , chemistry , fish <actinopterygii> , aqueous two phase system , acute toxicity , environmental chemistry , materials science , nanotechnology , biology , organic chemistry , fishery

A novel chamber for maintaining aqueous phase dispersions of nanoparticles (NPs) to enable improved toxicity testing in larval zebrafish was developed. Aqueous concentrations were within 80% of initial NP concentrations, and the 96‐h median lethal concentration (LC50) values were highly reproducible (coefficient of variation <0.16, n = 3 tests). Significantly lower toxicity for each NP tested (Ag, Cu, and TiO 2 NPs) in static beakers suggested that traditional acute toxicity tests may underestimate aqueous phase toxicity of NPs. Environ Toxicol Chem 2015;34:583–588. © 2014 SETAC

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