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Acute and chronic effects of diphenhydramine and sertraline mixtures in Ceriodaphnia dubia
Author(s) -
Goolsby Eric W.,
Mason Chase M.,
Wojcik James T.,
Jordan Alex M.,
Black Marsha C.
Publication year - 2013
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.2378
Subject(s) - ceriodaphnia dubia , diphenhydramine , chronic toxicity , toxicity , toxicology , acute toxicity , sertraline , environmental chemistry , pharmacology , chemistry , biology , medicine , antidepressant , hippocampus , histamine
Ceriodaphnia dubia were tested to evaluate the acute and chronic interactive effects of diphenhydramine and sertraline. Observed effects were compared with 2 reference toxicity models, the concentration addition model and the independent action model. Results indicate that the 2 drugs exhibit additive toxicity in C. dubia . In some cases, individually sublethal concentrations of the chemicals resulted in 100% mortality when combined, demonstrating the potentially severe impact of trace environmental contaminants. Environ Toxicol Chem 2013;32:2866–2869. © 2013 SETAC