Acute and chronic effects of diphenhydramine and sertraline mixtures in  Ceriodaphnia dubia | Zendy

Goolsby Eric W. | Zendy; Mason Chase M. | Zendy; Wojcik James T. | Zendy; Jordan Alex M. | Zendy; Black Marsha C. | Zendy

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Acute and chronic effects of diphenhydramine and sertraline mixtures in Ceriodaphnia dubia

Author(s) -

Goolsby Eric W.,

Mason Chase M.,

Wojcik James T.,

Jordan Alex M.,

Black Marsha C.

Publication year - 2013

Publication title -

environmental toxicology and chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 171

eISSN - 1552-8618

pISSN - 0730-7268

DOI - 10.1002/etc.2378

Subject(s) - ceriodaphnia dubia , diphenhydramine , chronic toxicity , toxicity , toxicology , acute toxicity , sertraline , environmental chemistry , pharmacology , chemistry , biology , medicine , antidepressant , hippocampus , histamine

Ceriodaphnia dubia were tested to evaluate the acute and chronic interactive effects of diphenhydramine and sertraline. Observed effects were compared with 2 reference toxicity models, the concentration addition model and the independent action model. Results indicate that the 2 drugs exhibit additive toxicity in C. dubia . In some cases, individually sublethal concentrations of the chemicals resulted in 100% mortality when combined, demonstrating the potentially severe impact of trace environmental contaminants. Environ Toxicol Chem 2013;32:2866–2869. © 2013 SETAC

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