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A single‐parameter logistic equation for fitting concentration‐response curves from standard acute ecotoxicity assays
Author(s) -
Trögl Josef,
Benediktová Kateřina,
Pilařová Věra,
Synek Václav
Publication year - 2013
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.2328
Subject(s) - ecotoxicity , logistic function , logistic regression , mathematics , statistics , biological system , chemistry , biology , organic chemistry , toxicity
A set of 69 concentration–response curves from 5 acute ecotoxicity assays was fitted with a 2‐parameter logistic equation. High correlation between values of regression parameters suggested similar slopes of the curves. This enabled derivation of the empirical single‐parameter logistic equation with the sole median effective concentration (EC50) parameter. Such an equation might be useful in the evaluation of lower‐quality (preliminary) experimental data and for the reduction of the number of test organisms and of testing costs. Environ Toxicol Chem 2013;32:2412–2416. © 2013 SETAC