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Linking survival and biomarker responses over time
Author(s) -
Jager Tjalling,
Hansen Bjørn Henrik
Publication year - 2013
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.2258
Subject(s) - biomarker , toxicodynamics , toxicogenomics , biology , computational biology , toxicokinetics , bioinformatics , genetics , gene , gene expression , pharmacokinetics
The practical usefulness of biomarkers is limited by the complexity of linking their responses to life‐history traits of the organisms (e.g., survival, growth, reproduction) over time. Here the authors present a first attempt to model biomarker responses and survival over time simultaneously with a toxicokinetic‐toxicodynamic approach. Even though more work is clearly needed, the present study provides a novel direction for interpreting biomarker responses and dynamically linking them to life‐history traits. Environ Toxicol Chem 2013;32:1842–1845. © 2013 SETAC